Sassuolo vs Lazio Predictions, Picks & Odds – 27/10/2026
Sassuolo vs Lazio Preview
Sassuolo sit 13th in the Serie A table with eight points from their opening matches, a return that reflects an inconsistent run of results. The Neroverdi have managed just one win and a draw in their last five outings across all competitions, and the loss of defender Fedde Leysen to a long-term ACL injury is a significant blow. Cas Odenthal has stepped into the backline, but settling a reshuffled defence against top-quality opposition will be no easy task.
Lazio, by contrast, arrive in sensational touch. Gennaro Gattuso's side occupy second place on 16 points, having won four and drawn one of their last five matches. A perfect away record of three wins from three this season underlines their travelling credentials. The return of midfielder Danilo Cataldi from a muscle problem further strengthens a squad already brimming with options, giving Gattuso the depth he needs to maintain intensity across a demanding fixture schedule.
Lazio's away record this season is flawless: three matches on the road, three victories. That perfect travelling form, combined with their position near the summit of Serie A, makes the away win at 2.24 the standout selection. Sassuolo have managed just one win and one draw at the MAPEI Stadium, offering little reason to back the hosts against such relentless opposition.
The visitors' defensive solidity further strengthens the case for backing Lazio to win. Gennaro Gattuso welcomes Danilo Cataldi back from a muscle injury, giving him a fully fit midfield to control proceedings. Sassuolo, meanwhile, lose centre-back Fedde Leysen to a long-term ACL injury, with Cas Odenthal stepping in as a less experienced replacement. That defensive disruption could prove costly against a side boasting five wins from six league outings.
Lazio hold a dominant head-to-head advantage, winning 14 of the 24 previous meetings between these clubs. Given Sassuolo's fragile form and their defensive reshuffle, the under 2.5 goals market at 2.24 also warrants consideration; Gattuso's side are disciplined enough to secure a controlled, low-scoring victory. The away win remains the primary recommendation for this fixture.
Questo articolo è a scopo informativo e non costituisce una raccomandazione di scommessa.
Trends to Know about Sassuolo vs Lazio
- Lazio won all three away fixtures
- Sassuolo lost three of last five
- Lazio lead head-to-head with 14 wins
Form & Statistics: Sassuolo vs Lazio
Sassuolo
Recent form
Season statistics (5)
Lazio
Recent form
Season statistics (5)
Lineups: Sassuolo vs Lazio
Sassuolo
Starters
- 1 Arijanet Murić
- 2 Van Der Brempt
- 3 Duje Ćaleta-Car
- 4 Cas Odenthal
- 5 Josh Doig
- 6 Vasilije Adžić
- 7 Nemanja Matić
- 8 Darryl Bakola
- 9 Domenico Berardi
- 10 Sebastiano Esposito
- 11 Armand Laurienté
Bench
- Andrea Consigli
- Gian Marco Ferrari
- Jeremy Toljan
- Matheus Henrique
- Kristian Thorstvedt
- Nedim Bajrami
- Samu Castillejo
- Gregoire Defrel
- Kieron Bowie
- Luca Lipani
- Cristian Volpato
Absent
- Ismaël Koné (injury)
- Fedde Leysen (injury)
- Daniel Boloca (Knee injury.)
- Fali Candé (Cruciate ligament injury.)
Lazio
Starters
- 1 Christos Mandas
- 2 Romano Floriani Mussolini
- 3 Danilho Doekhi
- 4 Oliver Provstgaard
- 5 Nuno Tavares
- 6 Davide Frattesi
- 7 Reda Belahyane
- 8 Kenneth Taylor
- 9 Gustav Isaksen
- 10 Tijjani Noslin
- 11 Mattia Zaccagni
Bench
- Ivan Provedel
- Mario Gila
- Nicolò Casale
- Elseid Hysaj
- Manuel Lazzari
- Danilo Cataldi
- Daichi Kamada
- Matteo Guendouzi
- Matteo Cancellieri
- Pedro
- Ciro Immobile
Absent
- Alessio Furlanetto (injury)
- Albert Gudmundsson (injury)
- Nicolò Rovella (injury)
- Samuel Gigot (injury)
- Luca Pellegrini (Thigh injury.)
- Patric (Sprained Ankle.)
Low confidence
Both formations mirror each other in a 4-3-3 vs 4-3-3 contest at the Mapei Stadium, though neither lineup carries strong confirmation, with both sides speculated from week-old sources. Treat the tactical picture as a reasonable working guide rather than settled fact ahead of Tuesday's session.
Sassuolo's shape relies on Berardi's creativity from the right channel, while Lazio's wide threat is built around Zaccagni on the opposite flank. The midfield battle, with Matić anchoring for the hosts against Frattesi's dynamism for the visitors, could prove the decisive contest in this Serie A encounter.
Sassuolo vs Lazio: Head-to-Head
Average statistics (recent meetings)
How to Watch Sassuolo vs Lazio Match?
What time is Sassuolo vs Lazio?
Sassuolo host Lazio on 27 October 2026, with kickoff scheduled for 17:30 local time.
Where is Sassuolo vs Lazio being played?
This fixture takes place at the MAPEI Stadium – Città del Tricolore in Reggio Emilia, Sassuolo's home ground.
How Can I Watch Sassuolo vs Lazio on TV and Live Stream?
Check local listings for Serie A broadcast details, as coverage varies by region across India.
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