Serie A

Sassuolo

27 Oct 2026 17:30

Lazio

Prediction:

Lazio to win 2.40

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SassuoloDraw Lazio

Sassuolo vs Lazio Predictions, Picks & Odds – 27/10/2026

Serie A · 9

Our prediction

2: Lazio to win

2.40 on Betfred · Confidence Medium

Odds recorded on 25 Oct 2026 at 23:26 · Odds are subject to change

Sassuolo vs Lazio Preview

Sassuolo sit thirteenth in Serie A and their recent run makes for uncomfortable reading, with just one win and a draw from the last five outings. The loss of centre-back Fedde Leysen to a long-term ACL injury is a significant blow, forcing Cas Odenthal into the starting line-up. At the MAPEI Stadium the hosts have managed two wins and a draw, but consistency has eluded them and confidence appears fragile heading into this fixture.

Lazio arrive in sensational form, occupying second place after remaining unbeaten across all six league matches this term. Gennaro Gattuso's side have won every away fixture so far, a perfect three from three on the road. The return of Danilo Cataldi from a muscle problem bolsters an already deep midfield. With fourteen victories in twenty-four previous meetings against Sassuolo, the historical dominance further tilts this contest in the visitors' favour.

Lazio's credentials for an away victory here are difficult to dispute. The Biancocelesti have won all three Serie A matches on the road this season, and their broader run of four wins and a draw from five fixtures places them second in the table. Sassuolo, by contrast, have managed only one win and a draw at the MAPEI Stadium, offering little defensive resilience to trouble a side in such rhythm.

The loss of Fedde Leysen to a long-term ACL injury further weakens Sassuolo's backline, with Cas Odenthal stepping in as a less established alternative. Lazio, meanwhile, welcome back Danilo Cataldi from a muscle problem, giving Gennaro Gattuso greater depth in midfield. That freshness matters across a congested schedule and tilts the personnel battle firmly in the visitors' favour.

An away win at 2.40 represents the standout selection. Lazio's head-to-head dominance is striking, having won fourteen of twenty-four previous meetings against Sassuolo. With over 2.5 goals landing regularly in Lazio's recent fixtures, 1.75 also merits consideration as a secondary pick. Questo articolo è a scopo informativo e non costituisce una raccomandazione di scommessa.

Trends to Know about Sassuolo vs Lazio

• Lazio boast a perfect away record
• Sassuolo missing key defender Leysen long-term
• Lazio won 14 of 24 past meetings

Both sides line up in a 4-3-3 formation, setting the stage for a mirror-image tactical contest at the Mapei Stadium. It is worth stressing, however, that neither XI has been confirmed by official sources, with both built from prior selections and injury adjustments, so changes before kickoff remain entirely plausible.

For Sassuolo, Domenico Berardi carries the creative burden in attack, while Lazio will look to Mattia Zaccagni to provide the cutting edge on the left flank. The midfield battle across both threes could prove the decisive battleground in what promises to be a closely contested Serie A fixture.

How to Watch Sassuolo vs Lazio Match?

What time is Sassuolo vs Lazio?

Sassuolo host Lazio at the MAPEI Stadium on Tuesday 27 October 2026, with kickoff scheduled for 17:30 BST.

Where is Sassuolo vs Lazio being played?

This fixture takes place at the MAPEI Stadium – Città del Tricolore in Reggio Emilia.

How Can I Watch Sassuolo vs Lazio on TV and Live Stream?

Check local Serie A broadcast listings for live coverage of Sassuolo vs Lazio on TV and streaming platforms.