Southampton vs Arsenal Predictions, Picks & Odds

Southampton vs Arsenal Game Details

Competition: FA Cup
Date: Saturday, 04 April 2026
Kick-off Time: 8:00 PM (UK time)
Venue: St. Mary’s Stadium
Live Stream (UK): TNT Sports

Southampton vs Arsenal Preview

Arsenal head to St Mary’s on Saturday looking to put their EFL Cup disappointment behind them when they face Southampton in the FA Cup quarter-finals. Mikel Arteta’s side were beaten by Manchester City at Wembley before the international break. As a result, this tie offers them an immediate chance to respond. Southampton, meanwhile, have quietly built momentum and will believe they can make life difficult for Arsenal on the South Coast.

Arsenal still have plenty to fight for in the closing weeks of the season. They remain in a strong position to win the Premier League, are still alive in Europe, and now stand just one win away from another FA Cup semi-final. Their fifth-round win over Mansfield Town was not convincing, but it got the job done.

On the other hand, Southampton come into the tie in excellent form. The Saints have beaten Doncaster Rovers, Leicester City and Fulham to reach the quarter-finals. Tonda Eckert’s side have taken 10 points from their last four league matches and are now firmly in the playoff picture. That makes this a far trickier test for Arsenal than it may first appear.

Both Teams Not to Score looks a great angle here given the recent pattern for both sides. Arsenal have seen this land in each of their last three matches, while Southampton have also seen it in their last two. Arsenal should dominate large spells of possession, and if they defend with the discipline expected of a top side, they have a good chance of keeping Southampton quiet.

Under 3.5 goals also makes plenty of sense because recent matches involving both teams have stayed below that line. In fact, both Arsenal and Southampton have seen under 3.5 goals in each of their last five games. Arsenal are likely to control the game, but Southampton’s recent form suggests they can stay compact enough to stop this from turning into a high-scoring affair.

Gabriel Jesus stands out in the anytime goalscorer market as his movement and sharpness in the box could prove decisive here. Arsenal should create enough chances against Southampton. Jesus is likely to start here and he can make the most of the chances Arsenal will create.