The Blues will recognise matchday traditions and Everton greats, as well as the first ever change of the giant Main Stand artwork.
Last month the Club held a vote to let supporters decide the subject of the 10-metre tall design to be showcased this weekend.
Thousands of Blues submitted their votes and the Holy Trinity design became the clear winner with 50 per cent of the three-way vote.
An iconic image of the legendary trio Colin Harvey, Howard Kendall and Alan Ball will now be unveiled this weekend – the second in a series of images to be displayed on the side of Goodison Park this season.
Following the success of last season's Retro Day when Hull City visited Goodison Park, a host of other matchday festivities are set to return.
Blues of all ages are invited to enjoy live music in the Fan Zone from Signed Sealed Delivered – a band playing covers from the 1960s through to the 1990s.
There will also be an adult Toffee lady in the Fan Zone, as well as special fan giveaways including Retro Day t-shirts, flat caps, rosettes and rattles for fans who are donning an old Everton shirt.
At St Luke's church, the Heritage Society will be hosting a special retro exhibition with an array of Everton memorabilia on show before kick-off. The group will continue to hold displays at the church before every home game this season.
Inside the stadium, retro videos will be shown on the big screens and fans are encouraged to be in their seats at least ten minutes before kick-off to be in with a chance of winning a 1995 replica shirt signed by Duncan Ferguson in the FanCam competition.
This weekend marks the 100th home league fixture against Aston Villa, which is the first time such a landmark has been reached in English football. To celebrate, one of the oldest programmes in the Club's collection – from the 1948/49 season – has been used to inspire the cover of the official matchday programme.